Persistent SARS-CoV-2 Spike Protein: Genomic Modulation, Immune Dysregulation, and Impaired Antibody Maturation

Author: John Murphy, CEO COVID 19 Long-haul Foundation Abstract The SARS-CoV-2 spike glycoprotein, central to viral entry and the target of mRNA vaccine platforms, has emerged as a persistent antigen…[...]

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COVID-19 and immune dysregulation: Genomic pathways, clinical manifestations, and therapeutic strategies

John Murphy, CEO & President, COVID-19 Long-haul Foundation Abstract SARS-CoV-2 provokes a uniquely heterogeneous and dynamic immune response that ranges from efficient viral control to fulminant hyperinflammation and prolonged immune…[...]

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Long Covid: Hormone Imbalances and/or Rather Complex Immune Dysregulations? 

Christian A Koch, Journal of the Endocrine Society, Volume 8, Issue 5, May 2024, bvae043, https://doi.org/10.1210/jendso/bvae043  Commentary Approximately 5% of all individuals infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)…[...]

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Immunological and Antigenic Signatures Associated with Chronic Illnesses after COVID-19 Vaccination

Bornali Bhattacharjee, Peiwen Lu, Valter Silva Monteiro, et. al. doi: https://doi.org/10.1101/2025.02.18.25322379 Yale Study Reveals Shocking Truth: Spike Protein Lingers – and Grows SUMMARY COVID-19 vaccines have prevented millions of COVID-19 deaths. Yet, a small fraction of the…[...]

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No evidence of durable trained immunity after two doses of adenovirus-vectored or mRNA COVID-19 vaccines

Natalie E. Stevens,1,2 Feargal J. Ryan,1,2 Nicole L. Messina,3,4 Stephen J. Blake,1,2 Todd S. Norton,1 Susie Germano,3 Jane James,1 Georgina L. Eden,1 Yee C. Tee,1,2 Miriam A. Lynn,1,2 Rochelle Botten,1 Simone E. Barry,5 Nigel Curtis,3,4 and David J. Lynn1,2 Published July 20, 2023 - September…[...]

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